Multinucleotide mutations cause false inferences of positive selection
نویسندگان
چکیده
منابع مشابه
Error-prone polymerase activity causes multinucleotide mutations in humans.
About 2% of human genetic polymorphisms have been hypothesized to arise via multinucleotide mutations (MNMs), complex events that generate SNPs at multiple sites in a single generation. MNMs have the potential to accelerate the pace at which single genes evolve and to confound studies of demography and selection that assume all SNPs arise independently. In this paper, we examine clustered mutat...
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